Phenibut

What is Phenibut?

Phenibut is a derivative of GABA (gamma-amino-butyric acid), a naturally occurring neurotransmitter. Phenibut is usually marketed as “Noofen” and “Citrocard” and is considered a tranquilizer. It was discovered in Soviet Union during the 1960s. Phenibut is sold as a nutritional supplement in the USA while in Russia it is used as medication to treat different kinds of conditions including posttraumatic stress disorder, anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders.

How does Phenibut work?

Phenibut is a close structural analogue of GABA. Similarly to GABA, phenibut is not able to cross the blood-brain barrier. The addition of a so called phenyl ring to phenibut enables this ability. Unlike other supplements for lowering stress levels that typically cause drowsiness, phenibut is adversely not affecting performance.

Effects of Phenibut

Based on its benefits, phenibut is categorized as a nootropic, antidepressant, neuroprotective and cardio-protective supplement. As these benefits are similar to other nootropic supplements, phenibut stands out by its anesthetic effects. Where other supplements induce a stimulatory effect, phenibut facilitates muscle relaxation, which in turn leads to a sound sleep. So phenibut acts as a tranquilizer for those who are unable to sleep due to depression, anxiety, fear of other psychic disorders.

Side-Effects of Phenibut

Low dosages are considered safe, and common side effects include lightheadedness, headache, fatigue, nausea, dehydration etc. Dehydration is a common side effect where users are suggested to drink plenty of water starting the very first day. In extreme cases, unconsciousness or memory loss may be a potential hazard, especially when using higher dosages. To avoid any complications, a consultation at a physician on dosage and scheduling, before using phenibut, is recommended.

Caution

Withdrawal symptoms can occur after prolonged usage with high dosages. Withdrawal symptoms include irritation, nausea, lack of appetite, sleeplessness, restlessness etc. One alleged solution is to withdraw steadily with decreasing dosages.

Special precaution must be taken pregnant or lactating women administering phenibut as very little data is available on its side effects in such circumstances.

It is usually not recommended to combine phenibut with other GABAergic drugs.

References

Phenibut and muscle relaxation https://books.google.es/books?id=vI6oBgAAQBAJ&printsec=frontcover&hl=de&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false