Coluracetam

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Coluracetam is a nootropic from the racetam family. It works as a high affinity choline uptake enhan.....

What is Coluracetam?

Coluracetam is a nootropic from the racetam family. It works as a high affinity choline uptake enhancer and was originally developed for use with Alzheimers disorder although it did not reach endpoints in clinical trials. Another clinical trial, carried out by BrainCells Inc have suggested that it would be a potential medication for depression and anxiety [1]. Its’ mechanisms of action and structure appear to be very distinct from other racetam compounds like Piracetam or Aniracetam.

How does Coluracetam work?

Coluracetam appears to interact with a process known as high affinity choline uptake, which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increased activity of cholinergic neurons caused by increased high affinity choline uptake rate, is a desired target for cognitive enhancement.

Effects of Coluracetam

By increasing choline uptake and synthesizing Acetylcholine, Coluracetam is thought to enhance cognition, improve memory and help rational decision making. The effects of Coluracetam are usually felt within 30 minutes after ingestion and wear off after about 3 hours.

Studies on Coluracetam

Most studies focus on Coluracetams ability to enhance choline uptake and its long lasting cognitive improvement after repeated administration [2]. One study has put attention on its possible help in treatment of the Alzheimer disease [3]. Further studies have found that when Coluracetam is taken over a longer period of time can be more effective than on short term [4].

Recommended Dosage / Usage Instructions

Recommendations vary, however most sources suggest 10mg to 30mg per day.

Coluracetam is water-soluble and can therefore be taken with water or any fluids.

Side-Effects of Coluracetam

Little to no side-effects are connected to Coluracetam at this point. Some report mild side-effects such as headache or nausea. In most cases these side effects were due to sudden higher dosages.

Caution

Pregnant or lactating women should consult a doctor before considering Coluracetam.

References

[1] - https://clinicaltrials.gov/ct2/show/NCT00621270?term=BCI-540&rank=1

[2] - MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats - http://www.ncbi.nlm.nih.gov/pubmed/18461272

[3] - Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3 - http://www.ncbi.nlm.nih.gov/pubmed/7748460

[4] - MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice -

 

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