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NSI-189 is an actively and clinically studied antidepressant currently under investigation by Neural.....

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What is NSI-189?

NSI-189 is an actively, clinically studied and approved antidepressant currently under investigation by Neuralstem, Inc. It has shown to significantly stimulate the generation of new neurons. According to completed studies, it was proven that NSI-189 improves cognitive deficits in depressed patients [1]. A few years ago, the FDA has permitted Neuralstem to pursue intended clinical development of NSI-189 for a variety of other neurological conditions, including traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder, stroke, and natural cognitive and memory decline in aging [4].

How does NSI-189 work?

The mechanism of action of NSI-189 appears to be activation of neurogenesis in the hippocampus and possible enlargement of this structure [1]. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [2]. A reason why nootropic value is attributed to NSI-189.

As most anti-depressant supplements, the idea behind NSI-189 is to attempt to alleviate depression by enhancing neurogenesis in the hippocampus-a brain structure implicated in learning, mood, and memory. The second study phase of Neuralstem concluded that NSI-189 may exhibit pro-cognitive properties associated with increases in prefrontal alpha coherence. Furthermore, NSI-189 produced qEEG changes in high-frequency alpha in the left posterior temporal and parietal regions in patients with major depressive disorder (MDD) [5].

Effects of NSI-189

In the two clinical studies conducted so far, NSI-189 has shown statistically significant effectiveness in reducing depressive symptoms and is therefore commonly offered as an anti-depressant supplement. NSI-189 is commonly taken as a mood booster.

Studies on NSI-189

Multiple studies suggest that NSI-189 is a powerful nootropic covering a very commonly occurring disorder in todays’ world, namely depression. One study to find out its efficacy in depression treatment specifically showed that it is a promising supplement in battling depression that is supported amongst many pharmaceutical institutions [3].

Recommended Dosage / Usage Instructions

Recommendations vary, however most sources suggest between 20mg and 60mg per day, spread across morning, midday and evening. For smart drugs beginners it is generally advised to start with smaller doses and gradually increase until the personal optimum is reached.

Side-Effects of NSI-189

NSI-189 has been found to be safe and well-tolerated with no major side-effects. Some of the side effects of NSI-189 include fatigue or mild sedation, difficulty waking and increased appetite. However, certain side-effects common amongst nootropics may occur when taking higher dosage that recommended, including headache, nausea, diarrhea or vomiting.


[1] - https://books.google.es/books?id=LoiECgAAQBAJ&pg=PA843&redir_esc=y#v=onepage&q&f=false

(Page 843)

[2] - Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed - https://www.google.com/patents/US8030492

[3] - A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients - http://www.ncbi.nlm.nih.gov/pubmed/26643541

[4] - FDA Approves Neuralstem To Treat Final Cohort In NSI-189 Phase Ib Trial In Major Depressive Disorder - http://investor.neuralstem.com/2013-04-22-FDA-Approves-Neuralstem-To-Treat-Final-Cohort-In-NSI-189-Phase-Ib-Trial-In-Major-Depressive-Disorder

[5] - Effects of NSI-189 phosphate, a neurogenic compound, on quantitative electroencephalography (qEEG) in patients with major depressive disorder (MDD) during a phase Ib randomized, double-blind, placebo-controlled, multiple-ascending-dose study - http://www.neuralstem.com/pdf/CiNP_Poster_189.pdf


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